ABSTRACT
Objective The aim of this study was to investigate the mental health status and sleep quality of university students after local outbreak of COVID-19, and to help them understand the psychological stress reaction and provide base for their mental health education. Methods A cross-sectional survey was conducted on the mental health status of university students in a Wuhan-based university. Results A total of 897 university students were enrolled in the study. Compared with the epidemic period, university students' mental health status and sleep quality has a great deal of difference in the aspects of gender, grade, discipline and specialty, physical exercise, as well as with their family relationships and so on. 64.26% students would like to talk to their peers or close friends, while only 2.71% would like to call a caring hotline or seek help from a psychologist. Conclusion After the local outbreak of COVID-19 in Wuhan was contained, the mental health status and sleep quality of more than half of the students improved. However, priority attention and care should be given to female students, senior students, those undertaking literature and history majors and those dissatisfied with family relationships.
Subject(s)
COVID-19ABSTRACT
SARS-COV-2 and all other coronaviruses express its 3 prime genes by forming sub-genomic RNA. As the genome of these virus exist in RNA form, only by profiling the relative abundance of these sgRNAs, can the viral transcriptome be revealed. Utilizing publically available meta-transcriptomic data generated from patient samples, we were able to infer the viral transcriptome in vivo, which is distinct from the in vitro one derived from cell culture. Inter-sample diversity was also observed and a sample specific transcript was identified. By doing the same analysis to MERS and SARS data, we were able to compare the three in terms of transcription. Among the differences, SARS-COV-2 has significantly elevated expression of the Spike gene, which may contribute to its high transmissibility. HighlightsO_LIThe in vivo transcriptome of SARS-CoV-2 revealed by sgRNA profiling, for 25 patient samples around the globe. C_LIO_LIThe Spike protein expression is an order of magnitude higher in SARS-CoV-2 than MERS-CoV or SARS-CoV, possibly contributing to the virus elevated transmissibility. C_LIO_LIThe in vivo SARS-CoV-2 transcriptomes, as inferred from human patient data was distinct from the in vitro one derived from cell line culture, all the accessory genes were up-regulated in vivo, suggesting intricate expression regulation mechanism for the small viral genome. C_LI